Effects of adding dexmedetomidine to ketamine on heart rate and blood pressure changs in psychiatric patients undergoing electroconvulsive therapy

Authors

  • Honarmand, Azim Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Nazemroaya, Behzad Dept. of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:

Introduction: Electroconvulsive therapy (ECT) is used to treat generalized seizures in psychiatric diseases. The aim of this study was to evaluate the effect of adding dexmedetomidine to ketamine on heart rate and blood pressure changes in in psychiatric patients undergoing electroconvulsive therapy (ECT) Materials and Methods: In this randomized, double-blind randomized clinical trial, taken place at the Alzahra Subspecialty Medical Center (Isfahan, Iran) between 2018- 2019. Fifty patients who were candidate for undergoing ECT entered the study and were divided into two groups namely A and B. The group A received a package containing 0.5 mg/kg succinylcholine and 1.5 mg/kg ketamine plus 0.1 mg/kg dexmedetomidine, and the group B received a medicine package containing 0.5 mg/kg succinylcholine and 1.5 mg/kg ketamine plus normal saline. The hemodynamic variables and side effects of the two drug classes were evaluated and compared to each other. Results: The durations of spontaneous respiratory recovery from seizure termination, end seizure to complete consciousness and recovery in the group A was significantly lower than the group B (P<0.001). However, the mean of systolic blood pressure and mean arterial blood pressure after the end of seizure was significantly less in the group A than the group B, but the mean of SPO2 in the fifth minute in the group B was significantly lower than the group A. However, the frequency of nausea and muscle pain in the group B was significantly higher than the group A. Conclusion: The addition of dexmedetomidine to ketamine in the candidate patients for ECT can shorten the duration of seizure, recovery time, respiratory depression, and also reduce complications such as nausea, muscle pain and oxygen depletion.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effects of Dexmedetomidine-Fentanyl Infusion on Blood Pressure and Heart Rate during Cardiac Surgery in Children

Background. The purpose of this study was to access the effects of dexmedetomidine-fentanyl infusion on blood pressure (BP) and heart rate (HR) before surgical stimulation, on their changes to skin incision, and on isoflurane requirement during cardiac surgery in children. Methods. This study had a prospective, randomized, and open-label design. Thirty-two children aged 1 month to 10 years unde...

full text

the effects of speech rate,prosodic features, and blurred speech on iranian efl learners listening comprehension

کلید واژه ها به زبان انگلیسی: effect of speech rate on listening comprehension, blurred speech,segmental and suprasegmental features,authentic speech,intelligibility, discrimination, omission, assimilation چکیده: سرعت مطالب شنیداری در کلام پیوسته بطور کلی همواره کابوسی بوده برای یادگیرنده های زبان دوم و بالاخص برای شنوندگان ایرانی. علی رغم عقل سلیم که کلام با سرعت کندتری فعالیتهای درک مطلب شن...

15 صفحه اول

The effect of low dose of ketamine on intraocular pressure in patients undergoing cataract surgery

Background: Cataract surgery is one of the most common surgeries in the world, especially in elderly patients, and often performed topically with sedative agents. Ketamine is one of the most commonly used agents and the effect of different doses on intraocular pressure is in dispute. The present study investigates the effect of a low dose of ketamine on intraocular pressure in patients undergoi...

full text

Comparing the Effects of Acceptance and Commitment Therapy and Meta-cognitive Therapy on Blood Pressure in Hemodialysis Patients

Background and Objectives: Dialysis patients encounter numerous psychological distress, aggravating their psycho-social problems. Currently, the third wave of psychological treatment has surpassed other treatments in solving the problems of these patients. The current study aimed to compare the effects of metacognitive therapy and Acceptance and Commitment Therapy (ACT) on blood pressure in hem...

full text

Gender and age effects on the ambulatory blood pressure and heart rate responses to antihypertensive therapy.

BACKGROUND The aim of this study was to assess potential differences in the 24-h antihypertensive response to treatment with the controlled-onset, extended-release (COER) calcium antagonist, verapamil in men versus women and older versus younger patients with hypertension. METHODS Meta-analyses were performed of three prospective randomized, double-blind, placebo-controlled trials with COER-v...

full text

Effects of Reflexology on Physiological Indices after Electroconvulsive Therapy in Depressed Patients Referred to Educational-Treatment Razi Psychiatric Center of Urmia, Iran

Background & Aim: The effects of general anesthesia and seizure caused by electroconvulsive therapy increase the risk of cardiovascular changes. This study aimed to evaluate the effect of reflexology on physiological indices after electroconvulsive therapy. Materials and Methods: This clinical trial was performed on 56 patients with depression, who were selected by stratified random sampling af...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 22  issue 2

pages  311- 316

publication date 2020-04

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023